Transformation of simple raw materials in a Ferment-Peptide Complex by a process that combines Natural ferment with a natural origin peptide
INNOVACTIVE LIPOFERM
a lipo-reducing and remodeling ferment with body and face shaping activity
TECHNOLOGY
BIO FERMENTATION
EFFICACY STUDIES
In vitro evaluation of the lipo-reducing activity
Face remodeling in vivo test
Body remodeling in vivo test
DOSAGE
3%
REGULATORY
EU AU US CA
Flowchart for Innovactive Barrierferm preparation
INNOVACTIVE FERMENTATION STRATEGY
Bacillus Subtilis originally obtained from Natto (the oldest Japanese food) during soybeans lactic fermentation, is fermented in the laboratory under controlled technological conditions in a specific medium with natural substrates and natural origin peptides having cosmetic properties.
During fermentation process, Bacillus Subtilis sp. Natto produces several bio actives peptides and enzymes playing key roles in skin cells.
The INNOVACTIVE FERMENTATION STRATEGY to obtain a Ferment-Peptide Complex is based on the addition of peptide during natural fermentation of Bacillus Subtilis grown with plant-derived nutrients.
INNOVACTIVE LIPOFERM
Ferment-Peptide Complex derived from natural fermentation in which Bacillus Subtilis grows in a specific medium including Tripeptide-41 to synergize with peptides produced by the bacteria, acting on lipolytic processes.
KEY ACTIVE INGREDIENTS AND THEIR FUNCTIONS
At the end of fermentation, the bacteria are filtered and lysed to obtain a concentrate rich in active ingredient such as:
- Vitamins Group B/K2/C
- Biologically active peptides
- Antioxidants
- Peptides and Proteins
- Catalase enzyme
- Lipase enzyme
Peptides and enzymes are titrated as total proteins and specific enzymatic activities which together with the B Group Vitamins make the Ferment-Peptide Complex particularly effective in several activities.
In the LIPOFERM particularly:
The LIPASE enzyme contained in the Bacillus Subtilis Ferment shows lipo-reducing and remodeling effects by inhibiting pre-adipocyte differentiation.
Tripeptide-41 stimulates lipolysis and contribute to the regulation of lipid mobilization. It promotes Brown adipocyte respiration, thermogenesis and the “browning” of white adipose deposits.
INNOVACTIVE LIPOFERM EFFICACY
- Lipo-reducing activity (slimming – anticellulite)
- Inhibition of pre-adipocyte differentia - tion
- Remodeling and redistribution activity of the body and face shaping
- Moisturizing activity
- Antioxidant protection from pollution, blue light and UV
LIPOFERM: EFFICACY TEST
IN VITRO LIPO-REDUCING
ACTIVITY ON ADIPOCYTES
Reduction triglycerides
accumulated in adipocytes
LIPOFERM: EFFICACY TEST
IN VIVO STUDIES
Face reshape activity
NEW EFFICACY IN VIVO TEST BODY REMODELING
Adipose tissue is a connective tissue made up of adipocytes of two types: white and brown and has the intrinsic ability to transform white adipocytes into brown adipocytes and vice versa. The coexistence of these cells is antithetical: the white ones accumulate lipids in the form of triglycerides (which have an energy reserve function, storing calories), while the brown ones burn them (that is, they burn calories by generating heat: thermogenesis) and this happens when there is a drop in body temperature.
In fact, the brown adipose tissue activates in response to a drop in temperature, as in our case, and by activating it consumes and therefore burns the white fat with a consequent increase in temperature.
Of course, during the efficacy test we observe and measure the various parameters at a given moment and we do not observe a prolonged and lasting trend over time, because as we can see in the results obtained, we can appreciate a lowering or raising of the temperature of the same area of the body after 28 days of twice a day application of our product containing 3% of Lipoferm, due precisely to the cold-hot variations which correspond to the activation of brown fat which burns white fat with a consequent increase in temperature.
In vivo efficacy test carried out using a cream containing 3% Lipoferm twice a day for 28 consecutive days
PHOTOS MADE WITH INFRARED THERMOGRAPHY
BODY CONTOUR REMODELING
NORMOMETRIC MEASUREMENTS
Technical product data
- INCI: Glycerin, Bacillus Ferment Filtrate, Tripeptide-41.
- Solubility: water soluble.
- pH: 6-8.
- Colour: colorless-yellowish
- Preservative Free
- Recommended dose: 3%
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