Transformation of simple raw materials in a Ferment-Peptide Complex by a process that combines Natural ferment with a natural origin peptide
INNOVACTIVE MICROFERM
a natural anti-microbial Ferment-Peptide Complex with a strong activity against bacteria pathogens and also C. Acnes
TECHNOLOGY
BIO FERMENTATION
EFFICACY STUDIES
In vitro comparative MIC evaluation vs Bacilferm
Including C. Acnes
Anti-Acne in vivo test
Sebum-balancing in vivo test
DOSAGE
1-3%
REGULATORY
EU AU US CA
Flowchart for Innovactive Barrierferm preparation
INNOVACTIVE FERMENTATION STRATEGY
Bacillus Subtilis originally obtained from Natto (the oldest Japanese food) during soybeans lactic fermentation, is fermented in the laboratory under controlled technological conditions in a specific medium with natural substrates and natural peptides having cosmetic properties.
During fermentation process, Bacillus Subtilis sp. Natto produces several bio actives peptides and enzymes playing key roles in skin cells.
The INNOVACTIVE FERMENTATION STRATEGY to obtain a Ferment-Peptide Complex is based on the addition of peptide during natural fermentation of Bacillus Subtilis grown with plant-derived nutrients.
INNOVACTIVE MICROFERM
Ferment-Peptide Complex derived from natural fermentation in which Bacillus Subtilis grows in a specific medium including a natural antimicrobial peptide which is the Oligopeptide-10, to synergize with peptides produced by the bacteria offering a strong antimicrobial activity against bacteria pathogens and also against C. Acnes.
KEY ACTIVE INGREDIENTS AND THEIR FUNCTIONS
At the end of fermentation, the bacteria are filtered and lysed to obtain a concentrate rich in active ingredient such as:
- Vitamins Group B/K2/C
- Biologically active peptides
- Antioxidants
- Peptides and Proteins
- Catalase enzyme
- Lipase enzyme
Peptides and enzymes are titrated as total proteins and specific enzymatic activities which together with the B Group Vitamins make the Ferment-Peptide Complex particularly effective in several activities.
In the MICROFERM particularly:
The Oligopeptide-10 is an anti-microbial derived from
plant amino acids with a broad spectrum activity against many types of microorganisms, including C. Acnes bacteria
We observe a synergistic antimicrobial effect with
antimicrobial peptide produced by the bacteria during the natural fermentation process.
INNOVACTIVE MICROFERM EFFICACY
- Broad antibacterial efficacy which makes it a valuable booster of the preservative system of finished products helping to reduce the necessary preservative system concentration
- Its marked activity against the C. Acnes bacterium makes it useful to treat acne symptoms
- Moisturizing activity
- Antioxidant protection from pollution, blue light and UV
- Anti-Acne activity
- Sebum balancing
IN VITRO COMPARATIVE EVALUATION OF MIC (MINIMUM INHIBITORY CONCENTRATION), INCLUDING C.ACNES
NEW EFFICACY IN VIVO TEST ANTI-ACNE
Acne is a rather common disorder characterized by inflammation of the pilosebaceous glands.
Typical of puberty, acne can still occur at any age, as it can be triggered by different types of factors, both internal and external such as: hormonal imbalances, bacterial causes, stress, genetic factors, drugs and particularly occlusive cosmetics.
As far as the bacterial causes are concerned, acne can be favored by the uncontrolled proliferation of Cutibacterium Acnes, a bacteria that normally lives on the skin under physiological conditions, however in the event of obstruction of the skin pores, this bacteria is able to multiply up to causing to the appearance of acne and inflammation.
INNOVACTIVE MICROFERM is a Ferment -Peptide Complex with a strong activity against bacteria pathogens and also C. Acnes which is why it is useful in the treatment of acne symptoms where, in addition to counteracting the bacterial proliferation of the responsible pathogen, it also carries out a moisturizing and protective action.
PHOTOGRAPHS taken with the OBSERV 520X, a closed system with standardized lighting conditions and then the parameters are quantified with Framescan Software
GEL CONTAINING MICROFERM 3%
T=0
T=28 days
Results obtained after 28 days of treatment: twice a day daily application of a gel containing 3% of MICROFERM for 4 weeks on hemiface against placebo.
ANTI-REDDING ACTIVITY
Soothing and calming action with evident reduction of skin redness and less inflammatory marks.
T=0
T=28 days
FLUORESCENCE SKIN ANALYSIS
BOOSTER ANTIMICROBIAL ACTIVITY ESPECIALLY AGAINST C. ACNES
T=0
T=28 days
SEBUM-REDUCTION ACTIVITY
NEW EFFICACY IN VIVO TEST 1 %
SEBUM-BALANCING EFFECT
REDUCTION IN THE VISIBILITY OF REDNESS
It was performed a clinical study with 10 subjects and a gel containing Microferm at 1% was applied twice a day for 14 days on one side of the face and the placebo on the other one.
The effect of the product was evaluated analysing the sebum reduction and the reduction of the visibility of redness in comparison with the variation obtained from a placebo.
SKIN SEBUM-BALANCING ANALYSIS
REDUCING EFFECT ON THE VISIBILITY OF REDNESS
RESULTS: GEL CONTAINING MICROFERM 1%
T=0
T=07 days
T=14 days
Technical product data
- INCI: Glycerin, Bacillus Ferment Filtrate, Oligopeptide-10.
- Solubility: water soluble.
- pH: 6-8.
- Colour: colorless-yellowish
- Preservative Free
- Recommended dose: 1-3%
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