Transformation of simple raw materials in a Ferment-Peptide Complex by a process that combines Natural ferment with a natural origin peptide

INNOVACTIVE WOMANFERM

Ferment-Peptide Complex to fight the signs associated with hormonal variations starting from Premenopause period.

TECHNOLOGY

BIO FERMENTATION

EFFICACY STUDIES

· Deep hydration
· Epidermal/Dermal density
· Echogenic density
· TEWL
· Protein Glycation
· Skin tightening
· Skin volumizing

DOSAGE

REGULATORY

EU AU CN KR US CA JP

Flowchart for Innovactive WOMANFERM preparation

INNOVACTIVE FERMENTATION STRATEGY

Saccharomyces Cerevisiae strain from fermented rice specifically selected based on its natural content of Ergosterol and the three main fatty acids Omega 3, Omega 6 and Omega 9.

The selection is carried out using cultivation techniques and biochemical analyzes to verify the content of these components.

The fermentation is carried out in the laboratory under controlled technological conditions in a specific medium, with natural nutrients (like glucose and soy peptones), and natural origin peptide, having cosmetic properties.

The INNOVACTIVE FERMENTATION STRATEGY to obtain a Ferment-Peptide Complex is based on the addition of a peptide during natural fermentation of Saccharomyces Cerevisiae grown with plant-derived nutrients to obtain synergies of active ingredients and cosmetic activities.

INNOVACTIVE WOMANFERM

Ferment-peptide Complex derived from natural fermentation in which Saccharomyces Cerevisiae with natural content of Ergosterol (precursor of Vitamin D) enriched by the fermentation process, and fatty acids omega 3, omega 6 and omega 9 which are the essential constituents of hydrolipidic film of the skin, grow in a specific medium , including the biomimetic peptide Acetyl tetrapeptide-2, to counteract facial skin changes associated with hormonal variations occurring from premenopause period such as:

· Flaccidity
· Loss of density, elasticity and tone
· Dryness
· Increased protein glycation
· Reduction of skin immune defenses

and keep the skin looking more youthful.

KEY ACTIVE INGREDIENTS AND THEIR FUNCTIONS

At the end of fermentation, the bacteria are lysed and filtered after centrifugation, to obtain a concentrate rich in active ingredients such as:

Ergosterol and fatty acids are titrated in each batch and make the Ferment-Peptide Complex together with the biomimetic peptide, particularly effective in counteract the effects of sagging skin, helping to fight the signs associated with hormonal variations and keep the skin looking youthful.

In the WOMANFERM particularly:

Saccharomyces ferment lysate filtrate

with natural Ergosterol content (precursor of Vitamin D) enriched by the fermentation process and fatty acids omega 3, omega 6 and omega 9 which are the essential constituents of the hydrolipidic film of the skin, it helps to increase dermal and epidermal density, makes the hydrolipidic film more compact and the skin barrier more resistant, bringing the skin back to an optimal physiological state and appearance.

Acetyl Tetrapeptide-2

Biomimetic peptide which helps the skin fight the signs associated with hormonal variation, starting from premenopause period , counteracting the effects of skin sagging and loss of tone due to aging and the force of gravity, stimulating skin’s immune defenses and increasing elasticity, firming and skin tightening efficacy.

INNOVACTIVE WOMANFERM® EFFICACY

With age, hormonal variations occur in a woman’s life which lead to stress, exhaustion and energy deficiency, but also loss of skin tone, dryness, thinning of the epidermis, poor production of Collagen/Elastin/HA, loss of brightness, appearance of age spots and increased loss of trans epidermal water due to lack of fatty acids in the hydrolipidic film.

All these skin changes are due to hormonal variations that occur starting from premenopause period and that we try to compensate bringing the skin back to an optimal physiological state and appearance in multiple ways:

In vivo efficacy test carried out using a Cream containing 3% of Womanferm twice a day for 28 consecutive days vs Placebo

Measurement of EPIDERMAL and DERMAL DENSITY using HIGH RESOLUTION 15-20 MHz Ultrasound (DUB SKIN SCANNER) and an average skin penetration of 16 mm

T28

ECHOGENIC DENSITY (quantity of acustic wave/area)

Measured by High Resolution 50 MHz Ultrasound (DUB SKIN SCANNER)

An increase in Echogenic density indicates an increase in the extracellular matrix, this means, a more organized skin structure and therefore a more compact dermal-epidermal junction.